The Cracked Potential of Boron-containing Compounds in Alzheimer's Disease

MA Soriano-Ursúa… - … Nervous System Agents …, 2023 - ingentaconnect.com
… as potential drugs considering multiple targets, suggested by … Hence, some BCC (precisely
some alkenylboronic acids) … -inflammatory and neuroprotective agent with multiple protective …

Boron-containing compounds on neurons: Actions and potential applications for treating neurodegenerative diseases

M Barrón-González, AV Montes-Aparicio… - Journal of Inorganic …, 2023 - Elsevier
… reactions can be observed in many biological targets [5]. The … diminished inflammation in
Alzheimer's disease (AD) in in- … used in PD treatment as a novel neuroprotective agent and drug…

COEXPEDIA: exploring biomedical hypotheses via co-expressions associated with medical subject headings (MeSH)

S Yang, CY Kim, S Hwang, E Kim, H Kim… - … acids research, 2017 - academic.oup.com
… When we submitted a group of 16 genes associated with Alzheimer's disease (… alkenylboronic
acids have a neuroprotective function and can affect multiple biological targets involved

[HTML][HTML] The role of microbiome in brain development and neurodegenerative diseases

V Nandwana, NK Nandwana, Y Das, M Saito, T Panda… - Molecules, 2022 - mdpi.com
… This review’s main goal is to summarize what is currently … further lead to the discovery of
two other drugs ixazomib and … novel neuroprotective agent and drug delivery method in the …

[HTML][HTML] Synthesis, in silico, and biological evaluation of a borinic tryptophan-derivative that induces melatonin-like amelioration of cognitive deficit in male rat

M Barrón-González, MC Rosales-Hernández… - International Journal of …, 2022 - mdpi.com
… of the boron moiety to the amino acid segment of L-tryptophan, … involved in the cognitive
deficit are unclear, but several … and borolatonin exert neuroprotection in hippocampal areas. In …

[HTML][HTML] Role of nanomedicine-based therapeutics in the treatment of CNS disorders

ZH Guo, S Khattak, MA Rauf, MA Ansari, MN Alomary… - Molecules, 2023 - mdpi.com
… activity on multiple targets, those that demonstrate a pro-survival … The challenge in
pharmaceutical research is discovering devices … In conclusion, SA NPs play a neuroprotective role …

Exploring the Multitarget Activity of Wedelolactone against Alzheimer's Disease: Insights from In Silico Study

DX Du, NHD Khang, NH Tri, PC Nam, NM Thong - ACS omega, 2023 - ACS Publications
… (19,20) Thus, drug developers are becoming interested in finding both AChE and BChE …
affinity for two target receptors. It interacts favorably with essential amino acid residues in these …

[HTML][HTML] Boron-based small molecules in disease detection and treatment (2013–2016)

S Thareja, M Zhu, X Ji, B Wang - Heterocyclic Communications, 2017 - degruyter.com
… to discover potent inhibitors of β-lactamases to target resistant … Arylboronic acids were reported
by several researchers as … a crucial role in neuroprotection from reactive oxygen species (…

[HTML][HTML] Boronic acid group: A cumbersome false negative case in the process of drug design

S Katsamakas, AG Papadopoulos… - Molecules, 2016 - mdpi.com
… found to present various biological activities: Neuroprotection [7]… Thus, several researchers
have tested various boronic acid … The enzyme autotaxin (ATX) was used as a biological target

Borolatonin limits cognitive deficit and neuron loss while increasing proBDNF in ovariectomised rats

M Barrón‐González, AM Rivera‐Antonio… - Fundamental & …, 2024 - Wiley Online Library
… (due to many epidemiological studies suggest this condition affects … to neuroprotection due
to the decreased levels in patients with AD [… Discovery of boron-containing compounds as Aβ …